Recent study by Resveratrol Partners shows that Longevinex suppressed SirT1 activation and had no effect on the other 6 Sirtuins

Resveratrol Partners is a start up California company that sells a supplement called Longevinex. This product consists of a combination of low dose resveratrol, quercetin and rice bran as filler. The company recently released results of a study they commissioned on the gene activation effects of Longevinex.

The results of this study strongly contradict the company's own emphatic claim that Longevinex activates the Sirt1 gene. In fact, the study data clearly confirms that low dose resveratrol combined with quercetin does not activate the SirT1 gene nor does it activate any of the other sirtuins. According to their own findings this combination resulted in a startling reduction of Sirt1 activation by a factor of 1.7 times.

This conclusion definitively validates Biotivia's position that, 1. A high dose of quality trans-resveratrol is required to obtain SirT1 activation and, 2. Quercetin suppresses SirT1 transcription. Below are excerpts taken directly from the Longevinex study. In the study Longevinex is referred to as NCM.

The mammalian sirtuin proteins are proposed to be critical mediators of the effect of CR and resveratrol; of the seven sirtuin genes identified in mice, only Sirt1 was changed by any treatment in this study (decreased -1.7-fold by Longevinex from the microarray;)

Moreover, Sirt1 expression was significantly decreased in expression

in the Longevinex mice from the microarray data (Figure 2D) and Sirt1 expression was not changed by any treatment according to the RT-PCR data

The ability of Transmax and Bioforte to activate the SirT1 gene was confirmed by the National Advertising Division of the National Better Business Bureau in their decision pursuant to Longevinex's complaint against Biotivia in February of this year. We here at Biotivia feel extremely gratified that once again our reliance upon peer reviewed scientific evidence and strict adherence to quality control and sound product design have been vindicated.